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- Title
CD4<sup>+</sup>CD25<sup>+</sup> suppressor t cells: more questions than answers.
- Authors
Shevach, Ethan M.
- Abstract
Several mechanisms control discrimination between self and non-self, including the thymic deletion of autoreactive T cells and the induction of anergy in the periphery. In addition to these passive mechanisms, evidence has accumulated for the active suppression of autoreactivity by a population of regulatory or suppressor T cells that co-express CD4 and CD25 (the interleukin-2 receptor α-chain). CD4+CD25+ T cells are powerful inhibitors of T-cell activation both in vivo and in vitro. The enhancement of suppressor-cell function might prove useful for the treatment of immune-mediated diseases, whereas the downregulation of these cells might be beneficial for the enhancement of the immunogenicity of vaccines that are specific for tumour antigens.
- Publication
Nature Reviews Immunology, 2002, Vol 2, Issue 6, p389
- ISSN
1474-1733
- Publication type
Academic Journal
- DOI
10.1038/nri821