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- Title
Epitope spreading in immune-mediated diseases: implications for immunotherapy.
- Authors
Vanderlugt, Carol L; Miller, Stephen D
- Abstract
Evidence continues to accumulate supporting the hypothesis that tissue damage during an immune response can lead to the priming of self-reactive T and/or B lymphocytes, regardless of the specificity of the initial insult. This review will focus primarily on epitope spreading at the T-cell level. Understanding the cellular and molecular basis of epitope spreading in various chronic immune-mediated human diseases and their animal models is crucial to understanding the pathogenesis of these diseases and to the ultimate goal of designing antigen-specific treatments.
- Publication
Nature reviews. Immunology, 2002, Vol 2, Issue 2, p85
- ISSN
1474-1733
- Publication type
Journal Article
- DOI
10.1038/nri724