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- Title
Transcriptional control of effector and memory CD8+ T cell differentiation.
- Authors
Kaech, Susan M; Cui, Weiguo
- Abstract
During an infection, T cells can differentiate into multiple types of effector and memory T cells, which help to mediate pathogen clearance and provide long-term protective immunity. These cells can vary in their phenotype, function and location, and in their long-term fate in terms of their ability to populate the memory T cell pool. Over the past decade, the signalling pathways and transcriptional programmes that regulate the formation of heterogeneous populations of effector and memory CD8(+) T cells have started to be characterized, and this Review discusses the major advances in these areas.
- Publication
Nature reviews. Immunology, 2012, Vol 12, Issue 11, p749
- ISSN
1474-1741
- Publication type
Journal Article
- DOI
10.1038/nri3307