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- Title
Integration of B cell responses through Toll-like receptors and antigen receptors.
- Authors
Rawlings, David J; Schwartz, Marc A; Jackson, Shaun W; Meyer-Bahlburg, Almut
- Abstract
Unlike other immune cells, B cells express both an antigen-specific B cell receptor (BCR) and Toll-like receptors (TLRs). Dual BCR and TLR engagement can fine-tune functional B cell responses, directly linking cell-intrinsic innate and adaptive immune programmes. Although most data regarding B cell-specific functions of the TLR signalling pathway have been obtained in mice, the discovery of patients with a deficiency in this pathway has recently provided an insight into human B cell responses. Here, we highlight the importance of the integration of signalling pathways downstream of BCRs and TLRs in modulating B cell function, focusing when possible on B cell-intrinsic roles.
- Publication
Nature reviews. Immunology, 2012, Vol 12, Issue 4, p282
- ISSN
1474-1741
- Publication type
Journal Article
- DOI
10.1038/nri3190