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- Title
Interrogating the repertoire: broadening the scope of peptide-MHC multimer analysis.
- Authors
Davis, Mark M; Altman, John D; Newell, Evan W
- Abstract
Labelling antigen-specific T cells with peptide-MHC multimers has provided an invaluable way to monitor T cell-mediated immune responses. A number of recent developments in this technology have made these multimers much easier to make and use in large numbers. Furthermore, enrichment techniques have provided a greatly increased sensitivity that allows the analysis of the naive T cell repertoire directly. Thus, we can expect a flood of new information to emerge in the coming years.
- Publication
Nature reviews. Immunology, 2011, Vol 11, Issue 8, p551
- ISSN
1474-1741
- Publication type
Review
- DOI
10.1038/nri3020