We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
MicroRNAs: the fine-tuners of Toll-like receptor signalling.
- Authors
O'Neill, Luke A; Sheedy, Frederick J; McCoy, Claire E
- Abstract
Toll-like receptor (TLR) signalling must be tightly regulated to avoid excessive inflammation and to allow for tissue repair and the return to homeostasis after infection and tissue injury. MicroRNAs (miRNAs) have emerged as important controllers of TLR signalling. Several miRNAs are induced by TLR activation in innate immune cells and these and other miRNAs target the 3' untranslated regions of mRNAs encoding components of the TLR signalling system. miRNAs are also proving to be an important link between the innate and adaptive immune systems, and their dysregulation might have a role in the pathogenesis of inflammatory diseases.
- Publication
Nature reviews. Immunology, 2011, Vol 11, Issue 3, p163
- ISSN
1474-1741
- Publication type
Journal Article
- DOI
10.1038/nri2957