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- Title
Recombination centres and the orchestration of V(D)J recombination.
- Authors
Schatz, David G; Ji, Yanhong
- Abstract
The initiation of V(D)J recombination by the recombination activating gene 1 (RAG1) and RAG2 proteins is carefully orchestrated to ensure that antigen receptor gene assembly occurs in the appropriate cell lineage and in the proper developmental order. Here we review recent advances in our understanding of how DNA binding and cleavage by the RAG proteins are regulated by the chromatin structure and architecture of antigen receptor genes. These advances suggest novel mechanisms for both the targeting and the mistargeting of V(D)J recombination, and have implications for how these events contribute to genome instability and lymphoid malignancy.
- Publication
Nature reviews. Immunology, 2011, Vol 11, Issue 4, p251
- ISSN
1474-1741
- Publication type
Journal Article
- DOI
10.1038/nri2941