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- Title
RNA-based antiviral immunity.
- Authors
Shou-Wei Ding; Ding, Shou-Wei
- Abstract
In eukaryotic RNA-based antiviral immunity, viral double-stranded RNA is recognized as a pathogen-associated molecular pattern and processed into small interfering RNAs (siRNAs) by the host ribonuclease Dicer. After amplification by host RNA-dependent RNA polymerases in some cases, these virus-derived siRNAs guide specific antiviral immunity through RNA interference and related RNA silencing effector mechanisms. Here, I review recent studies on the features of viral siRNAs and other virus-derived small RNAs from virus-infected fungi, plants, insects, nematodes and vertebrates and discuss the innate and adaptive properties of RNA-based antiviral immunity.
- Publication
Nature Reviews Immunology, 2010, Vol 10, Issue 9, p632
- ISSN
1474-1733
- Publication type
Academic Journal
- DOI
10.1038/nri2824