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- Title
Monoclonal antibodies: versatile platforms for cancer immunotherapy.
- Authors
Weiner, Louis M; Surana, Rishi; Wang, Shangzi
- Abstract
Antibodies are important therapeutic agents for cancer. Recently, it has become clear that antibodies possess several clinically relevant mechanisms of action. Many clinically useful antibodies can manipulate tumour-related signalling. In addition, antibodies exhibit various immunomodulatory properties and, by directly activating or inhibiting molecules of the immune system, antibodies can promote the induction of antitumour immune responses. These immunomodulatory properties can form the basis for new cancer treatment strategies.
- Publication
Nature reviews. Immunology, 2010, Vol 10, Issue 5, p317
- ISSN
1474-1741
- Publication type
Journal Article
- DOI
10.1038/nri2744