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- Title
Interplay between the TH17 and TReg cell lineages: a (co-)evolutionary perspective.
- Authors
Weaver, Casey T; Hatton, Robin D
- Abstract
The origins of the adaptive immune system and the basis for its unique association with vertebrate species have been a source of considerable speculation. In light of recent advances in our understanding of the developmental and functional links between the induced regulatory T cell and T helper 17 cell lineages, and their specialized relationship to the gut, we speculate that the co-evolution of these adaptive immune pathways might have given primitive vertebrates a means to benefit from the diversification of their commensal microbiota.
- Publication
Nature reviews. Immunology, 2009, Vol 9, Issue 12, p883
- ISSN
1474-1741
- Publication type
Journal Article
- DOI
10.1038/nri2660