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- Title
Autoimmune T cell responses in the central nervous system.
- Authors
Goverman, Joan
- Abstract
Autoreactive T cell responses have a crucial role in central nervous system (CNS) diseases such as multiple sclerosis. Recent data indicate that CNS autoimmunity can be mediated by two distinct lineages of CD4+ T cells that are defined by the production of either interferon-gamma or interleukin-17. The activity of these CD4+ T cell subsets within the CNS influences the pathology and clinical course of disease. New animal models show that myelin-specific CD8+ T cells can also mediate CNS autoimmunity. This Review focuses on recent progress in delineating the pathogenic mechanisms, regulation and interplay between these different T cell subsets in CNS autoimmunity.
- Publication
Nature reviews. Immunology, 2009, Vol 9, Issue 6, p393
- ISSN
1474-1741
- Publication type
Journal Article
- DOI
10.1038/nri2550