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- Title
GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation.
- Authors
I-Cheng Ho; Tzong-Shyuan Tai; Sung-Yun Pai; Ho, I-Cheng; Tai, Tzong-Shyuan; Pai, Sung-Yun
- Abstract
Many advances in our understanding of the molecules that regulate the development, differentiation and function of T cells have been made over the past few years. One important regulator of T-cell differentiation is the transcription factor GATA-binding protein 3 (GATA3). Although the main function of GATA3 is to act as a master transcription factor for the differentiation of T helper 2 (T(H)2) cells, new research has helped to uncover crucial functions of GATA3 in T cells that go beyond T(H)2-cell differentiation and that are important at earlier stages of haematopoietic and lymphoid-cell development. This Review focuses on the functions of GATA3 from early thymocyte development to effector T-cell differentiation. In addition, we discuss the interactions between GATA3 and other transcription factors and signalling pathways, and highlight the functional significance of the GATA3 protein structure.
- Publication
Nature Reviews Immunology, 2009, Vol 9, Issue 2, p125
- ISSN
1474-1733
- Publication type
Academic Journal
- DOI
10.1038/nri2476