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- Title
The alliance of sphingosine-1-phosphate and its receptors in immunity.
- Authors
Rivera, Juan; Proia, Richard L; Olivera, Ana
- Abstract
Sphingosine-1-phosphate (S1P) is a biologically active metabolite of plasma-membrane sphingolipids that is essential for immune-cell trafficking. Its concentration is increased in many inflammatory conditions, such as asthma and autoimmunity. Much of the immune function of S1P results from the engagement of a family of G-protein-coupled receptors (S1PR1-S1PR5). Recent findings on the role of S1P in immunosurveillance, the discovery of regulatory mechanisms in S1P-mediated immune-cell trafficking and new advances in understanding the mechanism by which S1P affects immune-cell function indicate that the alliance between S1P and its receptors has a fundamental role in immunity.
- Publication
Nature reviews. Immunology, 2008, Vol 8, Issue 10, p753
- ISSN
1474-1741
- Publication type
Journal Article
- DOI
10.1038/nri2400