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- Title
Germinal centres: role in B-cell physiology and malignancy.
- Authors
Klein, Ulf; Dalla-Favera, Riccardo
- Abstract
Over the past several years, studies on normal and malignant B cells have provided new insights into the unique physiology of the germinal centre (GC). In particular, advances in technology have allowed a more precise dissection of the phenotypes of GC B cells and the specific transcriptional programmes that are responsible for this phenotype. Furthermore, substantial progress has been made in the understanding of the mechanism controlling the exit of B cells from the GC and the decision to become a memory B cell or plasma cell. This Review focuses on these recent advances and discusses their implications for the pathogenesis of B-cell lymphomas.
- Publication
Nature reviews. Immunology, 2008, Vol 8, Issue 1, p22
- ISSN
1474-1741
- Publication type
Journal Article
- DOI
10.1038/nri2217