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- Title
The many paths to p38 mitogen-activated protein kinase activation in the immune system.
- Authors
Ashwell, Jonathan D
- Abstract
Signals emanating from many cell-surface receptors and environmental cues converge on mitogen-activated protein kinases (MAPKs), which in turn phosphorylate and activate various transcription factors and other molecular effectors. Members of the p38 MAPK family, which respond to pro-inflammatory cytokines and cellular stresses, are typically activated by serial phosphorylation and activation of upstream kinases (the MAPK cascade). In this Review, I highlight the recent studies that indicate that p38-subfamily members can also be activated by non-canonical mechanisms, at least one of which seems to have an important role in antigen-receptor-activated T cells. These alternative pathways might have particular relevance for cells that participate in immune and inflammatory responses.
- Publication
Nature reviews. Immunology, 2006, Vol 6, Issue 7, p532
- ISSN
1474-1733
- Publication type
Journal Article
- DOI
10.1038/nri1865