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- Title
Follicular B helper T cells in antibody responses and autoimmunity.
- Authors
Vinuesa, Carola G; Tangye, Stuart G; Moser, Bernhard; Mackay, Charles R
- Abstract
T-cell help for B cells is essential for high-affinity antibody responses and B-cell memory. Recently, the identity of a discrete follicular population of T cells that has a crucial role in this process has become clearer. Similar to primed CD4(+) T cells in the tonsils and memory CD4(+) T cells in the peripheral blood, this follicular population of T cells expresses CXC-chemokine receptor 5 (CXCR5). Owing to their distinct homing preferences and helper function, these T cells differ from T helper 1 and T helper 2 cells and have been denoted follicular B helper T cells. Here, we outline the central role of this subset in normal and pathological immune responses.
- Publication
Nature reviews. Immunology, 2005, Vol 5, Issue 11, p853
- ISSN
1474-1733
- Publication type
Journal Article
- DOI
10.1038/nri1714