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- Title
NF-kappaB: linking inflammation and immunity to cancer development and progression.
- Authors
Karin, Michael; Greten, Florian R
- Abstract
There has been much effort recently to probe the long-recognized relationship between the pathological processes of infection, inflammation and cancer. For example, epidemiological studies have shown that approximately 15% of human deaths from cancer are associated with chronic viral or bacterial infections. This Review focuses on the molecular mechanisms that connect infection, inflammation and cancer, and it puts forward the hypothesis that activation of nuclear factor-kappaB (NF-kappaB) by the classical, IKK-beta (inhibitor-of-NF-kappaB kinase-beta)-dependent pathway is a crucial mediator of inflammation-induced tumour growth and progression, as well as an important modulator of tumour surveillance and rejection.
- Publication
Nature reviews. Immunology, 2005, Vol 5, Issue 10, p749
- ISSN
1474-1733
- Publication type
Journal Article
- DOI
10.1038/nri1703