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- Title
Structure and function of the spleen.
- Authors
Mebius, Reina E; Kraal, Georg
- Abstract
The spleen combines the innate and adaptive immune system in a uniquely organized way. The structure of the spleen enables it to remove older erythrocytes from the circulation and leads to the efficient removal of blood-borne microorganisms and cellular debris. This function, in combination with a highly organized lymphoid compartment, makes the spleen the most important organ for antibacterial and antifungal immune reactivity. A better understanding of the function of this complex organ has been gained from recent studies, as outlined in this Review article.
- Publication
Nature reviews. Immunology, 2005, Vol 5, Issue 8, p606
- ISSN
1474-1733
- Publication type
Journal Article
- DOI
10.1038/nri1669