We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Anatomy of CD1-lipid antigen complexes.
- Authors
Moody, D Branch; Zajonc, Dirk M; Wilson, Ian A
- Abstract
CD1 proteins bind lipids to form antigen complexes that contact T-cell receptors and activate T cells. Recent crystal structures of CD1 proteins show that their antigen-binding grooves are composed of up to four pockets (A', C', F' and T') and two antigen portals (C' and F'). Although certain structural features are conserved among CD1 proteins, the grooves of CD1a, CD1b and CD1d differ in the number, shape and connectivity of their antigen-binding pockets. Here, we outline how the portals and pockets of CD1 antigen-binding grooves influence ligand specificity and facilitate the presentation of a surprisingly diverse set of antigenic lipids, glycolipids, lipopeptides and even small, non-lipidic molecules.
- Publication
Nature reviews. Immunology, 2005, Vol 5, Issue 5, p387
- ISSN
1474-1733
- Publication type
Journal Article
- DOI
10.1038/nri1605