We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma.
- Authors
Hawrylowicz, C M; O'Garra, A
- Abstract
Allergic diseases are caused by aberrant T-helper-2 immune responses in susceptible individuals. Both naturally occurring CD4(+)CD25(+) regulatory T cells and inducible populations of antigen-specific interleukin-10-secreting regulatory T cells inhibit these inappropriate immune responses in experimental models. This article discusses the evidence that regulatory T-cell function might be impaired in allergic and asthmatic disease and that certain therapeutic regimens might function, at least in part, to promote regulatory T-cell generation. Current research strategies seek to exploit these observations to improve the generation of allergen-specific regulatory T-cell populations with the potential to provide the safe and long-term alleviation of disease symptoms.
- Publication
Nature reviews. Immunology, 2005, Vol 5, Issue 4, p271
- ISSN
1474-1733
- Publication type
Journal Article
- DOI
10.1038/nri1589