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- Title
Roles of interferon-regulatory factors in T-helper-cell differentiation.
- Authors
Lohoff, Michael; Mak, Tak W
- Abstract
Members of the interferon-regulatory factor family of transcription factors have long been known to be intracellular mediators of the effects of interferons. In recent years, interferon-regulatory factors have also been shown to have an essential role in the differentiation of T helper cells, both by modulating the functions of antigen-presenting cells and by having direct effects on the T helper cells themselves. Depending on the interferon-regulatory factor involved, the differentiation of T helper cells to either T helper 1 cells or T helper 2 cells can be influenced. In this article, we provide an overview of this relatively new and still underappreciated role of interferon-regulatory factors.
- Publication
Nature reviews. Immunology, 2005, Vol 5, Issue 2, p125
- ISSN
1474-1733
- Publication type
Journal Article
- DOI
10.1038/nri1552