We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Fibrotic disease and the T<sub>H</sub>1/T<sub>H</sub>2 paradigm.
- Authors
Wynn, Thomas A.
- Abstract
Tissue fibrosis (scarring) is a leading cause of morbidity and mortality. Current treatments for fibrotic disorders, such as idiopathic pulmonary fibrosis, hepatic fibrosis and systemic sclerosis, target the inflammatory cascade, but they have been widely unsuccessful, largely because the mechanisms that are involved in fibrogenesis are now known to be distinct from those involved in inflammation. Several experimental models have recently been developed to dissect the molecular mechanisms of wound healing and fibrosis. It is hoped that by better understanding the immunological mechanisms that initiate, sustain and suppress the fibrotic process, we will achieve the elusive goal of targeted and effective therapeutics for fibroproliferative diseases.
- Publication
Nature Reviews Immunology, 2004, Vol 4, Issue 8, p583
- ISSN
1474-1733
- Publication type
Academic Journal
- DOI
10.1038/nri1412