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- Title
Opinion: Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses.
- Authors
Seung-Yong Seong; Matzinger, Polly
- Abstract
It is currently thought that immune responses are initiated by pathogen-associated molecular patterns or by tissue-derived danger/alarm signals. Here, we propose that these two groups of molecules might not be mutually exclusive. Many of them might be part of an evolutionarily ancient alert system in which the hydrophobic portions of biological molecules act, when exposed, as universal damage-associated molecular patterns to initiate repair, remodelling and immunity.
- Publication
Nature Reviews Immunology, 2004, Vol 4, Issue 6, p469
- ISSN
1474-1733
- Publication type
Academic Journal
- DOI
10.1038/nri1372