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- Title
Immune regulation by helminth parasites: cellular and molecular mechanisms.
- Authors
Maizels, Rick M; Yazdanbakhsh, Maria
- Abstract
Immunology was founded by studying the body's response to infectious microorganisms, and yet microbial prokaryotes only tell half the story of the immune system. Eukaryotic pathogens--protozoa, helminths, fungi and ectoparasites--have all been powerful selective forces for immune evolution. Often, as with lethal protozoal parasites, the focus has been on acute infections and the inflammatory responses they evoke. Long-lived parasites such as the helminths, however, are more remarkable for their ability to downregulate host immunity, protecting themselves from elimination and minimizing severe pathology in the host.
- Publication
Nature reviews. Immunology, 2003, Vol 3, Issue 9, p733
- ISSN
1474-1733
- Publication type
Journal Article
- DOI
10.1038/nri1183