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- Title
Establishment of vertebrate left-right asymmetry.
- Authors
Hamada, Hiroshi; Meno, Chikara; Watanabe, Daisuke; Saijoh, Yukio
- Abstract
The generation of morphological, such as left-right, asymmetry during development is an integral part of the establishment of a body plan. Until recently, the molecular basis of left-right asymmetry was a mystery, but studies indicate that Nodal and the Lefty proteins, transforming growth factor-beta-related molecules, have a central role in generating asymmetric signals. Although the initial mechanism of symmetry breaking remains unknown, developmental biologists are beginning to analyse the pathway that leads to left-right asymmetry establishment and maintenance.
- Publication
Nature reviews. Genetics, 2002, Vol 3, Issue 2, p103
- ISSN
1471-0056
- Publication type
Journal Article
- DOI
10.1038/nrg732