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- Title
Pleiotropy in complex traits: challenges and strategies.
- Authors
Solovieff, Nadia; Cotsapas, Chris; Lee, Phil H; Purcell, Shaun M; Smoller, Jordan W
- Abstract
Genome-wide association studies have identified many variants that each affects multiple traits, particularly across autoimmune diseases, cancers and neuropsychiatric disorders, suggesting that pleiotropic effects on human complex traits may be widespread. However, systematic detection of such effects is challenging and requires new methodologies and frameworks for interpreting cross-phenotype results. In this Review, we discuss the evidence for pleiotropy in contemporary genetic mapping studies, new and established analytical approaches to identifying pleiotropic effects, sources of spurious cross-phenotype effects and study design considerations. We also outline the molecular and clinical implications of such findings and discuss future directions of research.
- Publication
Nature reviews. Genetics, 2013, Vol 14, Issue 7, p483
- ISSN
1471-0064
- Publication type
Journal Article
- DOI
10.1038/nrg3461