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- Title
Enhancers: five essential questions.
- Authors
Pennacchio, Len A; Bickmore, Wendy; Dean, Ann; Nobrega, Marcelo A; Bejerano, Gill
- Abstract
It is estimated that the human genome contains hundreds of thousands of enhancers, so understanding these gene-regulatory elements is a crucial goal. Several fundamental questions need to be addressed about enhancers, such as how do we identify them all, how do they work, and how do they contribute to disease and evolution? Five prominent researchers in this field look at how much we know already and what needs to be done to answer these questions.
- Publication
Nature reviews. Genetics, 2013, Vol 14, Issue 4, p288
- ISSN
1471-0064
- Publication type
Review
- DOI
10.1038/nrg3458