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- Title
Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans.
- Authors
Adelman, Karen; Lis, John T
- Abstract
Recent years have witnessed a sea change in our understanding of transcription regulation: whereas traditional models focused solely on the events that brought RNA polymerase II (Pol II) to a gene promoter to initiate RNA synthesis, emerging evidence points to the pausing of Pol II during early elongation as a widespread regulatory mechanism in higher eukaryotes. Current data indicate that pausing is particularly enriched at genes in signal-responsive pathways. Here the evidence for pausing of Pol II from recent high-throughput studies will be discussed, as well as the potential interconnected functions of promoter-proximally paused Pol II.
- Publication
Nature reviews. Genetics, 2012, Vol 13, Issue 10, p720
- ISSN
1471-0064
- Publication type
Journal Article
- DOI
10.1038/nrg3293