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- Title
Uncovering the role of 5-hydroxymethylcytosine in the epigenome.
- Authors
Branco, Miguel R.; Ficz, Gabriella; Reik, Wolf
- Abstract
Just over 2 years ago, TET1 was found to catalyse the oxidation of 5-methylcytosine, a well-known epigenetic mark, into 5-hydroxymethylcytosine in mammalian DNA. The exciting prospect of a novel epigenetic modification that may dynamically regulate DNA methylation has led to the rapid accumulation of publications from a wide array of fields, from biochemistry to stem cell biology. Although we have only started to scratch the surface, interesting clues on the role of 5-hydroxymethylcytosine are quickly emerging.
- Publication
Nature Reviews Genetics, 2012, Vol 13, Issue 1, p7
- ISSN
1471-0056
- Publication type
Academic Journal
- DOI
10.1038/nrg3080