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- Title
Molecular spandrels: tests of adaptation at the genetic level.
- Authors
Barrett, Rowan D H; Hoekstra, Hopi E
- Abstract
Although much progress has been made in identifying the genes (and, in rare cases, mutations) that contribute to phenotypic variation, less is known about the effects that these genes have on fitness. Nonetheless, genes are commonly labelled as 'adaptive' if an allele has been shown to affect a phenotype with known or suspected functional importance or if patterns of nucleotide variation at the locus are consistent with positive selection. In these cases, the 'adaptive' designation may be premature and may lead to incorrect conclusions about the relationships between gene function and fitness. Experiments to test targets and agents of natural selection within a genomic context are necessary for identifying the adaptive consequences of individual alleles.
- Publication
Nature reviews. Genetics, 2011, Vol 12, Issue 11, p767
- ISSN
1471-0064
- Publication type
Journal Article
- DOI
10.1038/nrg3015