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- Title
Cleft lip and palate: understanding genetic and environmental influences.
- Authors
Dixon, Michael J; Marazita, Mary L; Beaty, Terri H; Murray, Jeffrey C
- Abstract
Clefts of the lip and/or palate (CLP) are common birth defects of complex aetiology. CLP can occur in isolation or as part of a broad range of chromosomal, Mendelian or teratogenic syndromes. Although there has been marked progress in identifying genetic and environmental triggers for syndromic CLP, the aetiology of the more common non-syndromic (isolated) forms remains poorly characterized. Recently, using a combination of epidemiology, careful phenotyping, genome-wide association studies and analysis of animal models, several distinct genetic and environmental risk factors have been identified and confirmed for non-syndromic CLP. These findings have advanced our understanding of developmental biology and created new opportunities for clinical translational research.
- Publication
Nature reviews. Genetics, 2011, Vol 12, Issue 3, p167
- ISSN
1471-0064
- Publication type
Journal Article
- DOI
10.1038/nrg2933