We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Small RNA sorting: matchmaking for Argonautes.
- Authors
Czech, Benjamin; Hannon, Gregory J
- Abstract
Small RNAs directly or indirectly impact nearly every biological process in eukaryotic cells. To perform their myriad roles, not only must precise small RNA species be generated, but they must also be loaded into specific effector complexes called RNA-induced silencing complexes (RISCs). Argonaute proteins form the core of RISCs and different members of this large family have specific expression patterns, protein binding partners and biochemical capabilities. In this Review, we explore the mechanisms that pair specific small RNA strands with their partner proteins, with an eye towards the substantial progress that has been recently made in understanding the sorting of the major small RNA classes - microRNAs (miRNAs) and small interfering RNAs (siRNAs) - in plants and animals.
- Publication
Nature reviews. Genetics, 2011, Vol 12, Issue 1, p19
- ISSN
1471-0064
- Publication type
Journal Article
- DOI
10.1038/nrg2916