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- Title
Analysing biological pathways in genome-wide association studies.
- Authors
Kai Wang; Mingyao Li; Hakonarson, Hakon; Wang, Kai; Li, Mingyao
- Abstract
Genome-wide association (GWA) studies have typically focused on the analysis of single markers, which often lacks the power to uncover the relatively small effect sizes conferred by most genetic variants. Recently, pathway-based approaches have been developed, which use prior biological knowledge on gene function to facilitate more powerful analysis of GWA study data sets. These approaches typically examine whether a group of related genes in the same functional pathway are jointly associated with a trait of interest. Here we review the development of pathway-based approaches for GWA studies, discuss their practical use and caveats, and suggest that pathway-based approaches may also be useful for future GWA studies with sequencing data.
- Publication
Nature Reviews Genetics, 2010, Vol 11, Issue 12, p843
- ISSN
1471-0056
- Publication type
Academic Journal
- DOI
10.1038/nrg2884