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- Title
The widespread regulation of microRNA biogenesis, function and decay.
- Authors
Krol, Jacek; Loedige, Inga; Filipowicz, Witold
- Abstract
MicroRNAs (miRNAs) are a large family of post-transcriptional regulators of gene expression that are approximately 21 nucleotides in length and control many developmental and cellular processes in eukaryotic organisms. Research during the past decade has identified major factors participating in miRNA biogenesis and has established basic principles of miRNA function. More recently, it has become apparent that miRNA regulators themselves are subject to sophisticated control. Many reports over the past few years have reported the regulation of miRNA metabolism and function by a range of mechanisms involving numerous protein-protein and protein-RNA interactions. Such regulation has an important role in the context-specific functions of miRNAs.
- Publication
Nature reviews. Genetics, 2010, Vol 11, Issue 9, p597
- ISSN
1471-0064
- Publication type
Journal Article
- DOI
10.1038/nrg2843