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- Title
Constraints and plasticity in genome and molecular-phenome evolution.
- Authors
Koonin, Eugene V; Wolf, Yuri I
- Abstract
Multiple constraints variously affect different parts of the genomes of diverse life forms. The selective pressures that shape the evolution of viral, archaeal, bacterial and eukaryotic genomes differ markedly, even among relatively closely related animal and bacterial lineages; by contrast, constraints affecting protein evolution seem to be more universal. The constraints that shape the evolution of genomes and phenomes are complemented by the plasticity and robustness of genome architecture, expression and regulation. Taken together, these findings are starting to reveal complex networks of evolutionary processes that must be integrated to attain a new synthesis of evolutionary biology.
- Publication
Nature reviews. Genetics, 2010, Vol 11, Issue 7, p487
- ISSN
1471-0064
- Publication type
Journal Article
- DOI
10.1038/nrg2810