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- Title
Mendelian disorders and multifactorial traits: the big divide or one for all?
- Authors
Antonarakis, Stylianos E; Chakravarti, Aravinda; Cohen, Jonathan C; Hardy, John
- Abstract
For the past century, Mendelian and multifactorial traits have existed at opposite ends of the disease spectrum in humans. Furthermore, the recent emphasis on genome-wide association studies for uncovering variants that underlie common diseases has risked deepening the divide - or has it? Four experienced human geneticists express their views on the changing landscape of human disease studies and the impact of new technologies and study designs on the age-old aim of connecting a genomic variant with its phenotypic consequences.
- Publication
Nature reviews. Genetics, 2010, Vol 11, Issue 5, p380
- ISSN
1471-0064
- Publication type
Review
- DOI
10.1038/nrg2793