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- Title
Genome-wide association studies in diverse populations.
- Authors
Rosenberg, Noah A; Huang, Lucy; Jewett, Ethan M; Szpiech, Zachary A; Jankovic, Ivana; Boehnke, Michael
- Abstract
Genome-wide association (GWA) studies have identified a large number of SNPs associated with disease phenotypes. As most GWA studies have been performed in populations of European descent, this Review examines the issues involved in extending the consideration of GWA studies to diverse worldwide populations. Although challenges exist with issues such as imputation, admixture and replication, investigation of a greater diversity of populations could make substantial contributions to the goal of mapping the genetic determinants of complex diseases for the human population as a whole.
- Publication
Nature reviews. Genetics, 2010, Vol 11, Issue 5, p356
- ISSN
1471-0064
- Publication type
Journal Article
- DOI
10.1038/nrg2760