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- Title
Small silencing RNAs: an expanding universe.
- Authors
Ghildiyal, Megha; Zamore, Phillip D
- Abstract
Since the discovery in 1993 of the first small silencing RNA, a dizzying number of small RNA classes have been identified, including microRNAs (miRNAs), small interfering RNAs (siRNAs) and Piwi-interacting RNAs (piRNAs). These classes differ in their biogenesis, their modes of target regulation and in the biological pathways they regulate. There is a growing realization that, despite their differences, these distinct small RNA pathways are interconnected, and that small RNA pathways compete and collaborate as they regulate genes and protect the genome from external and internal threats.
- Publication
Nature reviews. Genetics, 2009, Vol 10, Issue 2, p94
- ISSN
1471-0064
- Publication type
Journal Article
- DOI
10.1038/nrg2504