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- Title
Genome-wide approaches to studying chromatin modifications.
- Authors
Schones, Dustin E; Zhao, Keji
- Abstract
Over two metres of DNA is packaged into each nucleus in the human body in a manner that still allows for gene regulation. This remarkable feat is accomplished by the wrapping of DNA around histone proteins in repeating units of nucleosomes to form a structure known as chromatin. This chromatin structure is subject to various modifications that have profound influences on gene expression. Recently developed techniques to study chromatin modifications at a genome-wide scale are now allowing researchers to probe the complex components that make up epigenomes. Here we review genome-wide approaches to studying epigenomic structure and the exciting findings that have been obtained using these technologies.
- Publication
Nature reviews. Genetics, 2008, Vol 9, Issue 3, p179
- ISSN
1471-0064
- Publication type
Journal Article
- DOI
10.1038/nrg2270