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- Title
The road to modularity.
- Authors
Wagner, Günter P; Pavlicev, Mihaela; Cheverud, James M
- Abstract
A network of interactions is called modular if it is subdivided into relatively autonomous, internally highly connected components. Modularity has emerged as a rallying point for research in developmental and evolutionary biology (and specifically evo-devo), as well as in molecular systems biology. Here we review the evidence for modularity and models about its origin. Although there is an emerging agreement that organisms have a modular organization, the main open problem is the question of whether modules arise through the action of natural selection or because of biased mutational mechanisms.
- Publication
Nature reviews. Genetics, 2007, Vol 8, Issue 12, p921
- ISSN
1471-0064
- Publication type
Journal Article
- DOI
10.1038/nrg2267