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- Title
Histone lysine demethylases: emerging roles in development, physiology and disease.
- Authors
Shi, Yang
- Abstract
The discovery of an increasing number of histone demethylases has highlighted the dynamic nature of the regulation of histone methylation, a key chromatin modification that is involved in eukaryotic genome and gene regulation. A flurry of recent studies has offered glimpses into the specific biological roles of these enzymes and their potential connections to human diseases. These advances have also catalysed a resurgence of interest in epigenetic regulators as potential therapeutic targets.
- Publication
Nature reviews. Genetics, 2007, Vol 8, Issue 11, p829
- ISSN
1471-0064
- Publication type
Journal Article
- DOI
10.1038/nrg2218