We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The distribution of fitness effects of new mutations.
- Authors
Eyre-Walker, Adam; Keightley, Peter D
- Abstract
The distribution of fitness effects (DFE) of new mutations is a fundamental entity in genetics that has implications ranging from the genetic basis of complex disease to the stability of the molecular clock. It has been studied by two different approaches: mutation accumulation and mutagenesis experiments, and the analysis of DNA sequence data. The proportion of mutations that are advantageous, effectively neutral and deleterious varies between species, and the DFE differs between coding and non-coding DNA. Despite these differences between species and genomic regions, some general principles have emerged: advantageous mutations are rare, and those that are strongly selected are exponentially distributed; and the DFE of deleterious mutations is complex and multi-modal.
- Publication
Nature reviews. Genetics, 2007, Vol 8, Issue 8, p610
- ISSN
1471-0056
- Publication type
Journal Article
- DOI
10.1038/nrg2146