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- Title
Heterochromatin revisited.
- Authors
Grewal, Shiv I S; Jia, Songtao
- Abstract
The formation of heterochromatin, which requires methylation of histone H3 at lysine 9 and the subsequent recruitment of chromodomain proteins such as heterochromatin protein HP1, serves as a model for the role of histone modifications and chromatin assembly in epigenetic control of the genome. Recent studies in Schizosaccharomyces pombe indicate that heterochromatin serves as a dynamic platform to recruit and spread a myriad of regulatory proteins across extended domains to control various chromosomal processes, including transcription, chromosome segregation and long-range chromatin interactions.
- Publication
Nature reviews. Genetics, 2007, Vol 8, Issue 1, p35
- ISSN
1471-0056
- Publication type
Journal Article
- DOI
10.1038/nrg2008