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- Title
Genetics of autoimmune diseases--disorders of immune homeostasis.
- Authors
Gregersen, Peter K; Behrens, Timothy W
- Abstract
In the past few years, our extensive knowledge of the mammalian immune system and our increasing ability to understand the genetic causes of complex human disease have opened a window onto the pathways that lead to autoimmune disorders. In addition to the well-established role of genetic variation that affects the major histocompatibility complex, a number of rare and common variants that affect a range of immunological pathways are now known to have important influences on the phenotypic diversity that is seen among autoimmune diseases. Recent studies have also highlighted a previously unanticipated interplay between the innate and adaptive immune system, providing a new direction for research in this field.
- Publication
Nature reviews. Genetics, 2006, Vol 7, Issue 12, p917
- ISSN
1471-0056
- Publication type
Journal Article
- DOI
10.1038/nrg1944