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- Title
Genetics of Parkinson disease: paradigm shifts and future prospects.
- Authors
Farrer, Matthew James
- Abstract
Parkinson disease is a complex, multifactorial neurodegenerative disease. Although a heritable basis was originally thought unlikely, recent studies have implicated several genes in its pathogenesis, and molecular findings now allow accurate diagnosis and challenge past criteria for defining Parkinson disease. Most importantly, genetic insights provide the rationale for new strategies for prevention or therapy, and have led to animal models of disease in which these strategies can be tested. Neuroprotective therapies can now be designed to slow or halt disease progression in affected subjects and asymptomatic carriers.
- Publication
Nature reviews. Genetics, 2006, Vol 7, Issue 4, p306
- ISSN
1471-0056
- Publication type
Journal Article
- DOI
10.1038/nrg1831