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- Title
Functional mapping — how to map and study the genetic architecture of dynamic complex traits.
- Authors
Rongling Wu; Min Lin
- Abstract
The development of any organism is a complex dynamic process that is controlled by a network of genes as well as by environmental factors. Traditional mapping approaches for analysing phenotypic data measured at a single time point are too simple to reveal the genetic control of developmental processes. A general statistical mapping framework, called functional mapping, has been proposed to characterize, in a single step, the quantitative trait loci (QTLs) or nucleotides (QTNs) that underlie a complex dynamic trait. Functional mapping estimates mathematical parameters that describe the developmental mechanisms of trait formation and expression for each QTL or QTN. The approach provides a useful quantitative and testable framework for assessing the interplay between gene actions or interactions and developmental changes.
- Publication
Nature Reviews Genetics, 2006, Vol 7, Issue 3, p229
- ISSN
1471-0056
- Publication type
Academic Journal
- DOI
10.1038/nrg1804