We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The role of double-strand break repair - insights from human genetics.
- Authors
O'Driscoll, Mark; Jeggo, Penny A
- Abstract
The efficient repair of DNA double-strand breaks is crucial in safeguarding the genomic integrity of organisms. Responses to double-strand breaks include complex signal-transduction, cell-cycle-checkpoint and repair pathways. Defects in these pathways lead to several human disorders with pleiotropic clinical features. Dissection of the molecular basis that underlies the diverse clinical features is enhancing our understanding of the damage-response mechanisms and their role in development, and might ultimately facilitate treatment.
- Publication
Nature reviews. Genetics, 2006, Vol 7, Issue 1, p45
- ISSN
1471-0056
- Publication type
Journal Article
- DOI
10.1038/nrg1746