We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Mapping by admixture linkage disequilibrium: advances, limitations and guidelines.
- Authors
Smith, Michael W; O'Brien, Stephen J
- Abstract
Mapping by admixture linkage disequilibrium (MALD) is a theoretically powerful, although unproven, approach to mapping genetic variants that are involved in human disease. MALD takes advantage of long-range haplotypes that are generated by gene flow among recently admixed ethnic groups, such as African-Americans and Latinos. Under ideal circumstances, MALD will have more power to detect some genetic variants than other types of genome-wide association study that are carried out among more ethnically homogeneous populations. It will also require 200-500 times fewer markers, providing a significant economic advantage. The MALD approach is now being applied, with results expected in the near future.
- Publication
Nature reviews. Genetics, 2005, Vol 6, Issue 8, p623
- ISSN
1471-0056
- Publication type
Journal Article
- DOI
10.1038/nrg1657