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- Title
Opinion: Co-evolution of X-chromosome inactivation and imprinting in mammals.
- Authors
Reik, Wolf; Lewis, Annabelle
- Abstract
Recent studies have revealed mechanistic parallels between imprinted X-chromosome inactivation and autosomal imprinting. We suggest that neither mechanism was present in ancestral egg-laying mammals, and that both arose when the evolution of the placenta exerted selective pressure to imprint growth-related genes. We also propose that non-coding RNAs and histone modifications were adopted for the imprinting of growth suppressors on the X chromosome and on autosomes. This provides a unified hypothesis for the evolution of X-chromosome inactivation and imprinting.
- Publication
Nature Reviews Genetics, 2005, Vol 6, Issue 5, p403
- ISSN
1471-0056
- Publication type
Academic Journal
- DOI
10.1038/nrg1602