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- Title
Opinion: Conserved non-genic sequences-an unexpected feature of mammalian genomes.
- Authors
Dermitzakis, Emmanouil T.; Reymond, Alexandre; Antonarakis, Stylianos E.
- Abstract
Mammalian genomes contain highly conserved sequences that are not functionally transcribed. These sequences are single copy and comprise approximately 1-2% of the human genome. Evolutionary analysis strongly supports their functional conservation, although their potentially diverse, functional attributes remain unknown. It is likely that genomic variation in conserved non-genic sequences is associated with phenotypic variability and human disorders. So how might their function and contribution to human disorders be examined?
- Publication
Nature Reviews Genetics, 2005, Vol 6, Issue 2, p151
- ISSN
1471-0056
- Publication type
Academic Journal
- DOI
10.1038/nrg1527